3GGS
Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoro-2'-deoxyadenosine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Purine nucleoside phosphorylase | polymer | 311 | 34400.2 | 3 | UniProt (P00491) Pfam (PF01048) | Homo sapiens (Human) | PNP, Inosine phosphorylase |
| 2 | D, KA, O, Z (A, C, B) | 5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL | non-polymer | 269.2 | 4 | Chemie (2FD) | |||
| 3 | AA, BA, CA, DA, E... (C, A, B) | SULFATE ION | non-polymer | 96.1 | 30 | Chemie (SO4) | |||
| 4 | LA, MA, NA (A, B, C) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 289 (UniProt: P00491)
| PDB | External Database | Details |
|---|---|---|
| Lys -21 | - | expression tag |
| Glu -20 | - | expression tag |
| Thr -19 | - | expression tag |
| Ala -18 | - | expression tag |
| Ala -17 | - | expression tag |
| Ala -16 | - | expression tag |
| Lys -15 | - | expression tag |
| Phe -14 | - | expression tag |
| Glu -13 | - | expression tag |
| Arg -12 | - | expression tag |
| Gln -11 | - | expression tag |
| His -10 | - | expression tag |
| Met -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Gln 201 | Glu 201 | engineered mutation |
| Asp 243 | Asn 243 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 103200.7 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 3958.8 | |
| All* | Total formula weight | 107159.6 |
