3GGA

HIV Protease inhibitors with pseudo-symmetric cores

3GGA の概要

• エントリーDOI: 10.2210/pdb3gga/pdb
• 関連するPDBエントリー: 1MUI 3GGV 3GGX
• 分子名称: V-1 protease, methyl [(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-yl]carbamate (3 entities in total)
• 機能のキーワード: pseudo-symmetrical hiv protease inhibitors, hydrolase, protease
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 65526.40

構造登録者

Stoll, V.S. (登録日: 2009-02-27, 公開日: 2009-05-26, 最終更新日: 2024-02-21)

• 主引用文献: Degoey, D.A.,Grampovnik, D.J.,Flentge, C.A.,Flosi, W.J.,Chen, H.J.,Yeung, C.M.,Randolph, J.T.,Klein, L.L.,Dekhtyar, T.,Colletti, L.,Marsh, K.C.,Stoll, V.,Mamo, M.,Morfitt, D.C.,Nguyen, B.,Schmidt, J.M.,Swanson, S.J.,Mo, H.,Kati, W.M.,Molla, A.,Kempf, D.J.; 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.; J.Med.Chem., 52:2571-2586, 2009; PubMed: 19323562; DOI: 10.1021/jm900044w

実験手法

X-RAY DIFFRACTION (2.5 Å)