3GEQ

Structural basis for the chemical rescue of Src kinase activity

3GEQ の概要

• エントリーDOI: 10.2210/pdb3geq/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total)
• 機能のキーワード: kinase, chemical rescue, pp2, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Cell membrane (By similarity): P00523
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65886.63

構造登録者

Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A. (登録日: 2009-02-25, 公開日: 2009-04-28, 最終更新日: 2023-09-06)

• 主引用文献: Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A.; Comparative analysis of mutant tyrosine kinase chemical rescue.; Biochemistry, 48:3378-3386, 2009; PubMed: 19260709; DOI: 10.1021/bi900057g

実験手法

X-RAY DIFFRACTION (2.2 Å)