3GEQ

Structural basis for the chemical rescue of Src kinase activity

3GEQ の概要

分子名称Proto-oncogene tyrosine-protein kinase Src, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total)
機能のキーワードkinase, chemical rescue, pp2, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
由来する生物種Gallus gallus (bantam,chickens)
細胞内の位置Cell membrane (By similarity) P00523
ポリマー鎖数2
分子量合計65886.63
構造登録者
Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A. (登録日: 2009-02-25, 公開日: 2009-04-28, 最終更新日: 2011-07-13)
主引用文献
Muratore, K.E.,Seeliger, M.A.,Wang, Z.,Fomina, D.,Neiswinger, J.,Havranek, J.J.,Baker, D.,Kuriyan, J.,Cole, P.A.
Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry, 48:3378-3386, 2009
PubMed: 19260709 (主引用文献が同じPDBエントリー)
DOI: 10.1021/bi900057g
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
NMR情報
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.273130.4%2.6%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード