3GDD

An inverted anthraquinone-DNA crystal structure

Summary for 3GDD

Entry DOI	10.2210/pdb3gdd/pdb
Descriptor	5'-D((BRU)PAPGPG)-3', MAGNESIUM ION, N,N'-(9,10-dioxo-9,10-dihydroanthracene-2,7-diyl)bis[2-(dimethylamino)acetamide], ... (4 entities in total)
Functional Keywords	anthraquinone, telomere dna sequence, drug-dna complex, dna
Total number of polymer chains	2
Total formula weight	4249.55
Authors	Subirana, J.A.,De Luchi, D.,Wright, G.,Gouyette, C. (deposition date: 2009-02-24, release date: 2010-03-09, Last modification date: 2024-02-21)
Primary citation	De Luchi, D.,Uson, I.,Wright, G.,Gouyette, C.,Subirana, J.A. Structure of a stacked anthraquinone-DNA complex Acta Crystallogr.,Sect.F, 66:1019-1022, 2010 Cited by PubMed Abstract: The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G.G and A.UBr reverse Watson-Crick base pairs. PubMed: 20823516 DOI: 10.1107/S1744309110030034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation