3GC9

The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor

3GC9 の概要

• エントリーDOI: 10.2210/pdb3gc9/pdb
• 関連するPDBエントリー: 3GC7 3GC8
• 分子名称: Mitogen-activated protein kinase 11, SODIUM ION, 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-[1-(1-methylethyl)piperidin-4-yl]-3,4-dihydroquinazolin-2(1H)-one, ... (5 entities in total)
• 機能のキーワード: serine/threonine kinase, drug design, selectivity, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85266.73

構造登録者

Scapin, G.,Patel, S.B. (登録日: 2009-02-21, 公開日: 2009-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Patel, S.B.,Cameron, P.M.,O'Keefe, S.J.,Frantz-Wattley, B.,Thompson, J.,O'Neill, E.A.,Tennis, T.,Liu, L.,Becker, J.W.,Scapin, G.; The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.; Acta Crystallogr.,Sect.D, 65:777-785, 2009; PubMed: 19622861; DOI: 10.1107/S090744490901600X

実験手法

X-RAY DIFFRACTION (2.05 Å)