3GC5
tRNA-guanine transglycosylase in complex with 6-amino-4-(2-aminoethyl)-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
Summary for 3GC5
Entry DOI | 10.2210/pdb3gc5/pdb |
Related | 2Z7K 3EOS 3EOU 3GC4 3GE7 3GEV |
Descriptor | Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-4-(2-aminoethyl)-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total) |
Functional Keywords | drug design, tim barrel, trna modification, glycosyltransferase, metal-binding, queuosine biosynthesis, transferase, trna processing |
Biological source | Zymomonas mobilis |
Total number of polymer chains | 1 |
Total formula weight | 43540.69 |
Authors | Ritschel, T.,Heine, A.,Klebe, G. (deposition date: 2009-02-21, release date: 2009-12-15, Last modification date: 2024-03-20) |
Primary citation | Ritschel, T.,Kohler, P.C.,Neudert, G.,Heine, A.,Diederich, F.,Klebe, G. How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase Chemmedchem, 4:2012-2023, 2009 Cited by PubMed: 19894214DOI: 10.1002/cmdc.200900343 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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