3GC5

tRNA-guanine transglycosylase in complex with 6-amino-4-(2-aminoethyl)-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Summary for 3GC5

Entry DOI	10.2210/pdb3gc5/pdb
Related	2Z7K 3EOS 3EOU 3GC4 3GE7 3GEV
Descriptor	Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-4-(2-aminoethyl)-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
Functional Keywords	drug design, tim barrel, trna modification, glycosyltransferase, metal-binding, queuosine biosynthesis, transferase, trna processing
Biological source	Zymomonas mobilis
Total number of polymer chains	1
Total formula weight	43540.69
Authors	Ritschel, T.,Heine, A.,Klebe, G. (deposition date: 2009-02-21, release date: 2009-12-15, Last modification date: 2024-03-20)
Primary citation	Ritschel, T.,Kohler, P.C.,Neudert, G.,Heine, A.,Diederich, F.,Klebe, G. How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase Chemmedchem, 4:2012-2023, 2009 Cited by PubMed: 19894214 DOI: 10.1002/cmdc.200900343 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation