3GC4
tRNA-guanine transglycosylase in complex with inhibitor
Summary for 3GC4
| Entry DOI | 10.2210/pdb3gc4/pdb |
| Related | 2Z7K 3EOS 3EOU 3GC5 3GE7 3GEV |
| Descriptor | Queuine tRNA-ribosyltransferase, 6-amino-4-[2-(benzylamino)ethyl]-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ZINC ION, ... (5 entities in total) |
| Functional Keywords | drug design, tim barrel, trna modification, glycosyltransferase, metal-binding, queuosine biosynthesis, transferase, trna processing |
| Biological source | Zymomonas mobilis |
| Total number of polymer chains | 1 |
| Total formula weight | 43815.00 |
| Authors | Ritschel, T.,Heine, A.,Klebe, G. (deposition date: 2009-02-21, release date: 2009-12-15, Last modification date: 2023-11-01) |
| Primary citation | Ritschel, T.,Kohler, P.C.,Neudert, G.,Heine, A.,Diederich, F.,Klebe, G. How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase Chemmedchem, 4:2012-2023, 2009 Cited by PubMed: 19894214DOI: 10.1002/cmdc.200900343 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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