3GC4

tRNA-guanine transglycosylase in complex with inhibitor

3GC4 の概要

• エントリーDOI: 10.2210/pdb3gc4/pdb
• 関連するPDBエントリー: 2Z7K 3EOS 3EOU 3GC5 3GE7 3GEV
• 分子名称: Queuine tRNA-ribosyltransferase, 6-amino-4-[2-(benzylamino)ethyl]-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ZINC ION, ... (5 entities in total)
• 機能のキーワード: drug design, tim barrel, trna modification, glycosyltransferase, metal-binding, queuosine biosynthesis, transferase, trna processing
• 由来する生物種: Zymomonas mobilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43815.00

構造登録者

Ritschel, T.,Heine, A.,Klebe, G. (登録日: 2009-02-21, 公開日: 2009-12-15, 最終更新日: 2023-11-01)

• 主引用文献: Ritschel, T.,Kohler, P.C.,Neudert, G.,Heine, A.,Diederich, F.,Klebe, G.; How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase; Chemmedchem, 4:2012-2023, 2009; PubMed: 19894214; DOI: 10.1002/cmdc.200900343

実験手法

X-RAY DIFFRACTION (1.8 Å)