3GBB

X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution

Summary for 3GBB

• Entry DOI: 10.2210/pdb3gbb/pdb
• Related: 1YCJ 3GBA
• Descriptor: Glutamate receptor, ionotropic kainate 1, (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid (3 entities in total)
• Functional Keywords: ionotropic glutamate receptors, iglur5, ligand-binding core, weak agonist, membrane protein
• Biological source: Rattus norvegicus (rat); More
• Total number of polymer chains: 2
• Total formula weight: 58735.42

Authors

Frydenvang, K.,Naur, P.,Gajhede, M.,Kastrup, J.S. (deposition date: 2009-02-19, release date: 2009-03-17, Last modification date: 2023-11-01)

• Primary citation: Frydenvang, K.,Lash, L.L.,Naur, P.,Postila, P.A.,Pickering, D.S.,Smith, C.M.,Gajhede, M.,Sasaki, M.,Sakai, R.,Pentikainen, O.T.,Swanson, G.T.,Kastrup, J.S.; Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine; J.Biol.Chem., 284:14219-14229, 2009; PubMed: 19297335; DOI: 10.1074/jbc.M808547200

Experimental method

X-RAY DIFFRACTION (2.1 Å)