3G8O

Progesterone Receptor with bound Pyrrolidine 1

「3G8N」から置き換えられました

3G8O の概要

• エントリーDOI: 10.2210/pdb3g8o/pdb
• 関連するPDBエントリー: 3HQ5
• 分子名称: Progesterone receptor, N~2~-[4-cyano-3-(trifluoromethyl)phenyl]-N,N-dimethyl-N~2~-(2,2,2-trifluoroethyl)-L-alaninamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: progesterone receptor, steroid hormone receptor, nuclear receptor, pr, progesterone, alpha helical sandwich, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, transcription regulation, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61387.44

構造登録者

Thompson, S.K.,Washburn, D.G.,Madauss, K.P.,Williams, S.P.,Stewart, E.L. (登録日: 2009-02-12, 公開日: 2010-02-16, 最終更新日: 2023-09-06)

主引用文献

Thompson, S.K.,Washburn, D.G.,Frazee, J.S.,Madauss, K.P.,Hoang, T.H.,Lapinski, L.,Grygielko, E.T.,Glace, L.E.,Trizna, W.,Williams, S.P.,Duraiswami, C.,Bray, J.D.,Laping, N.J.
Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Bioorg.Med.Chem.Lett., 19:4777-4780, 2009

PubMed Abstract: Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed. Members of this class of N-alkylpyrrolidines demonstrate potent and highly selective partial agonism of the progesterone receptor, and one of these analogs was shown to be efficacious upon oral dosing in the OVX rat model of estrogen opposition.

PubMed: 19595590
DOI: 10.1016/j.bmcl.2009.06.055

実験手法

X-RAY DIFFRACTION (1.9 Å)