3G6H

Src Thr338Ile inhibited in the DFG-Asp-Out conformation

3G6H の概要

• エントリーDOI: 10.2210/pdb3g6h/pdb
• 関連するPDBエントリー: 3G6G
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide (3 entities in total)
• 機能のキーワード: cancer, imatinib resistance, dsa compounds, kinase, dfg-asp-out, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Cell membrane (By similarity): P00523
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66109.00

構造登録者

Seeliger, M.A.,Ranjitkar, P.,Kasap, C.,Shan, Y.,Shaw, D.E.,Shah, N.P.,Kuriyan, J.,Maly, D.J. (登録日: 2009-02-06, 公開日: 2009-03-24, 最終更新日: 2023-09-06)

• 主引用文献: Seeliger, M.A.,Ranjitkar, P.,Kasap, C.,Shan, Y.,Shaw, D.E.,Shah, N.P.,Kuriyan, J.,Maly, D.J.; Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations; Cancer Res., 69:2384-2392, 2009; PubMed: 19276351; DOI: 10.1158/0008-5472.CAN-08-3953

実験手法

X-RAY DIFFRACTION (2.35 Å)