3G61

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Summary for 3G61

• Entry DOI: 10.2210/pdb3g61/pdb
• Related: 3G5U 3G60
• Descriptor: Multidrug resistance protein 1a, (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (2 entities in total)
• Functional Keywords: p-glycoprotein, pgp, multidrug resistance, membrane protein, cycle peptides, atp-binding, nucleotide-binding
• Biological source: Mus musculus (mouse)
• Total number of polymer chains: 2
• Total formula weight: 286545.46

Authors

Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G. (deposition date: 2009-02-05, release date: 2009-03-24, Last modification date: 2024-02-21)

• Primary citation: Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G.; Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.; Science, 323:1718-1722, 2009; PubMed: 19325113; DOI: 10.1126/science.1168750

Experimental method

X-RAY DIFFRACTION (4.35 Å)