3G5E

Human aldose reductase complexed with IDD 740 inhibitor

Summary for 3G5E

Entry DOI	10.2210/pdb3g5e/pdb
Related	1Z3N
Descriptor	Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid, ... (4 entities in total)
Functional Keywords	aldose reductase, inhibition, diabetes, acetylation, cataract, cytoplasm, nadp, oxidoreductase, phosphoprotein, polymorphism
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37303.38
Authors	Podjarny, A.D.,Van Zandt, M.C. (deposition date: 2009-02-05, release date: 2009-03-24, Last modification date: 2024-03-20)
Primary citation	Van Zandt, M.C.,Doan, B.,Sawicki, D.R.,Sredy, J.,Podjarny, A.D. Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Bioorg.Med.Chem.Lett., 19:2006-2008, 2009 Cited by PubMed: 19250825 DOI: 10.1016/j.bmcl.2009.02.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation