3G5E
Human aldose reductase complexed with IDD 740 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldose reductase | polymer | 319 | 36180.6 | 1 | UniProt (P15121) Pfam (PF00248) | Homo sapiens (Human) | AR, Aldehyde reductase |
| 2 | B (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | C (A) | 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid | non-polymer | 377.3 | 1 | Chemie (Q74) | |||
| 4 | D (A) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Ile 4 | Leu 5 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36180.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1122.8 | |
| All* | Total formula weight | 37303.4 |
