3G5E

Human aldose reductase complexed with IDD 740 inhibitor

3G5E の概要

• エントリーDOI: 10.2210/pdb3g5e/pdb
• 関連するPDBエントリー: 1Z3N
• 分子名称: Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid, ... (4 entities in total)
• 機能のキーワード: aldose reductase, inhibition, diabetes, acetylation, cataract, cytoplasm, nadp, oxidoreductase, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37303.38

構造登録者

Podjarny, A.D.,Van Zandt, M.C. (登録日: 2009-02-05, 公開日: 2009-03-24, 最終更新日: 2024-03-20)

• 主引用文献: Van Zandt, M.C.,Doan, B.,Sawicki, D.R.,Sredy, J.,Podjarny, A.D.; Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.; Bioorg.Med.Chem.Lett., 19:2006-2008, 2009; PubMed: 19250825; DOI: 10.1016/j.bmcl.2009.02.037

実験手法

X-RAY DIFFRACTION (1.8 Å)