3G3N
PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one
Summary for 3G3N
Entry DOI | 10.2210/pdb3g3n/pdb |
Descriptor | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one, ZINC ION, ... (4 entities in total) |
Functional Keywords | pde7, crystal, inhibitor complex, alternative splicing, camp, hydrolase, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm: Q13946 |
Total number of polymer chains | 1 |
Total formula weight | 37293.16 |
Authors | Castano, T.,Wang, H. (deposition date: 2009-02-02, release date: 2009-04-28, Last modification date: 2024-02-21) |
Primary citation | Castano, T.,Wang, H.,Campillo, N.E.,Ballester, S.,Gonzalez-Garcia, C.,Hernandez, J.,Perez, C.,Cuenca, J.,Perez-Castillo, A.,Martinez, A.,Huertas, O.,Gelpi, J.L.,Luque, F.J.,Ke, H.,Gil, C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors Chemmedchem, 4:866-876, 2009 Cited by PubMed: 19350606DOI: 10.1002/cmdc.200900043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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