3G3E

Crystal structure of human D-amino acid oxidase in complex with hydroxyquinolin-2(1H)

Summary for 3G3E

Entry DOI	10.2210/pdb3g3e/pdb
Descriptor	D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 3-hydroxyquinolin-2(1H)-one, ... (4 entities in total)
Functional Keywords	d-amino acid oxidase, fad, flavoprotein, oxidoreductase, peroxisome
Biological source	Homo sapiens (human)
Cellular location	Peroxisome: P14920
Total number of polymer chains	4
Total formula weight	163736.84
Authors	Duplantier, A.,Liu, S. (deposition date: 2009-02-02, release date: 2009-06-23, Last modification date: 2023-09-06)
Primary citation	Duplantier, A.J.,Becker, S.L.,Bohanon, M.J.,Borzilleri, K.A.,Chrunyk, B.A.,Downs, J.T.,Hu, L.Y.,El-Kattan, A.,James, L.C.,Liu, S.,Lu, J.,Maklad, N.,Mansour, M.N.,Mente, S.,Piotrowski, M.A.,Sakya, S.M.,Sheehan, S.,Steyn, S.J.,Strick, C.A.,Williams, V.A.,Zhang, L. Discovery, SAR, and pharmacokinetics of a novel 3-Hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors J.Med.Chem., 52:3576-3585, 2009 Cited by PubMed: 19438227 DOI: 10.1021/jm900128w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation