3G1R
Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A
Summary for 3G1R
Entry DOI | 10.2210/pdb3g1r/pdb |
Descriptor | 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide, ... (4 entities in total) |
Functional Keywords | finasteride complex, bile acid catabolism, cytoplasm, disease mutation, intrahepatic cholestasis, lipid metabolism, nadp, oxidoreductase, steroid metabolism |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81057.87 |
Authors | Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. (deposition date: 2009-01-30, release date: 2009-06-09, Last modification date: 2023-09-06) |
Primary citation | Drury, J.E.,Di Costanzo, L.,Penning, T.M.,Christianson, D.W. Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. J.Biol.Chem., 284:19786-19790, 2009 Cited by PubMed: 19515843DOI: 10.1074/jbc.C109.016931 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.701 Å) |
Structure validation
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