3G1Q

Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state

3G1Q の概要

• エントリーDOI: 10.2210/pdb3g1q/pdb
• 分子名称: Sterol 14-alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: sterol 14-alpha demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, membrane protein, sterol biosynthesis
• 由来する生物種: Trypanosoma brucei
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 206370.56

構造登録者

Lepesheva, G.I.,Hargrove, T.Y.,Harp, J.,Wawrzak, Z.,Waterman, M.R.,Park, H. (登録日: 2009-01-30, 公開日: 2009-10-06, 最終更新日: 2023-09-06)

• 主引用文献: Lepesheva, G.I.,Park, H.W.,Hargrove, T.Y.,Vanhollebeke, B.,Wawrzak, Z.,Harp, J.M.,Sundaramoorthy, M.,Nes, W.D.,Pays, E.,Chaudhuri, M.,Villalta, F.,Waterman, M.R.; Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.; J.Biol.Chem., 285:1773-1780, 2010; PubMed: 19923211; DOI: 10.1074/jbc.M109.067470

実験手法

X-RAY DIFFRACTION (1.89 Å)