3FZM

Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors

Summary for 3FZM

• Entry DOI: 10.2210/pdb3fzm/pdb
• Related: 3FZF 3FZH 3FZK 3FZL
• Descriptor: Heat shock cognate 71 kDa protein, BAG family molecular chaperone regulator 1, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-(quinolin-6-ylmethylamino)purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitri le, ... (4 entities in total)
• Functional Keywords: hsp70, hsc70, bag1, heat shock, chaperone, protein folding, adenosine, nucleotide, nucleotide exchange factor, small molecule inhibitor, atp-binding, nucleotide-binding, stress response, apoptosis
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P11142; Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 4: Cytoplasm: Q99933
• Total number of polymer chains: 2
• Total formula weight: 55782.27

Authors

Dokurno, P.,Williamson, D.S.,Murray, J.B.,Surgenor, A.E. (deposition date: 2009-01-26, release date: 2009-03-17, Last modification date: 2023-11-01)

• Primary citation: Williamson, D.S.,Borgognoni, J.,Clay, A.,Daniels, Z.,Dokurno, P.,Drysdale, M.J.,Foloppe, N.,Francis, G.L.,Graham, C.J.,Howes, R.,Macias, A.T.,Murray, J.B.,Parsons, R.,Shaw, T.,Surgenor, A.E.,Terry, L.,Wang, Y.,Wood, M.,Massey, A.J.; Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design; J.Med.Chem., 52:1510-1513, 2009; PubMed: 19256508; DOI: 10.1021/jm801627a

Experimental method

X-RAY DIFFRACTION (2.3 Å)