3FX6

X-RAY crystallographic studies on the complex of carboxypeptidase A with the inhibitor using alpha-nitro ketone as the zinc-binding group

Summary for 3FX6

Entry DOI	10.2210/pdb3fx6/pdb
Descriptor	Carboxypeptidase A1, ZINC ION, (2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid, ... (4 entities in total)
Functional Keywords	alpha-nitro ketone, inhibitor, hydrolase, carboxypeptidase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
Biological source	Bos taurus (Bovine)
Cellular location	Secreted, extracellular space: P00730
Total number of polymer chains	3
Total formula weight	104514.34
Authors	Wang, S.F.,Jin, J.Y.,Tian, G.R. (deposition date: 2009-01-20, release date: 2009-08-25, Last modification date: 2023-11-01)
Primary citation	Wang, S.F.,Tian, G.R.,Zhang, W.Z.,Jin, J.Y. Characterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A Bioorg.Med.Chem.Lett., 19:5009-5011, 2009 Cited by PubMed: 19646864 DOI: 10.1016/j.bmcl.2009.07.060 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.851 Å)

Structure validation