Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with Ferric Catechol

Summary for 3FW4

DescriptorNeutrophil gelatinase-associated lipocalin, FE (III) ION, CATECHOL, ... (7 entities in total)
Functional Keywords8-stranded anti-parallel beta barrel, 310-helix, glycoprotein, pyrrolidone carboxylic acid, secreted, transport protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted P80188
Total number of polymer chains3
Total molecular weight63491.67
Clifton, M.C.,Strong, R.K. (deposition date: 2009-01-16, release date: 2010-05-05, Last modification date: 2011-07-13)
Primary citation
Bao, G.,Clifton, M.,Hoette, T.M.,Mori, K.,Deng, S.X.,Qiu, A.,Viltard, M.,Williams, D.,Paragas, N.,Leete, T.,Kulkarni, R.,Li, X.,Lee, B.,Kalandadze, A.,Ratner, A.J.,Pizarro, J.C.,Schmidt-Ott, K.M.,Landry, D.W.,Raymond, K.N.,Strong, R.K.,Barasch, J.
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Nat.Chem.Biol., 6:602-609, 2010
PubMed: 20581821 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.402
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2864 0.9% 2.3% 14.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23