3FW0

Structure of Peptidyl-alpha-hydroxyglycine alpha-Amidating Lyase (PAL) bound to alpha-hydroxyhippuric acid (non-peptidic substrate)

3FW0 の概要

• エントリーDOI: 10.2210/pdb3fw0/pdb
• 関連するPDBエントリー: 3FVZ
• 分子名称: Peptidyl-glycine alpha-amidating monooxygenase, MERCURY (II) ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: beta propeller, zinc, calcium, mercury, lyase, peptide amidation, substrate, hydroxyhippuric acid, alternative splicing, cleavage on pair of basic residues, copper, cytoplasmic vesicle, glycoprotein, membrane, metal-binding, monooxygenase, multifunctional enzyme, oxidoreductase, phosphoprotein, sulfation, transmembrane, vitamin c
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein: P14925
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37550.52

構造登録者

Chufan, E.E.,De, M.,Eipper, B.A.,Mains, R.E.,Amzel, L.M. (登録日: 2009-01-16, 公開日: 2009-09-01, 最終更新日: 2024-04-03)

• 主引用文献: Chufan, E.E.,De, M.,Eipper, B.A.,Mains, R.E.,Amzel, L.M.; Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme.; Structure, 17:965-973, 2009; PubMed: 19604476; DOI: 10.1016/j.str.2009.05.008

実験手法

X-RAY DIFFRACTION (2.52 Å)