3FVL

Crystallogic studies on the Complex of Carboxypeptidase A with inhibitors using alpha-hydroxy ketone as zinc-binding group

Summary for 3FVL

• Entry DOI: 10.2210/pdb3fvl/pdb
• Descriptor: Carboxypeptidase A1, ZINC ION, (2R)-2-benzyl-5-hydroxy-4-oxopentanoic acid, ... (4 entities in total)
• Functional Keywords: carboxypeptidase a, alpha-hydroxy ketone, inhibitor, carboxypeptidase, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
• Biological source: Bos taurus (Bovine)
• Cellular location: Secreted, extracellular space: P00730
• Total number of polymer chains: 3
• Total formula weight: 104373.30

Authors

Wang, S.F.,Jin, J.-Y.,Tian, G.R. (deposition date: 2009-01-16, release date: 2010-01-12, Last modification date: 2024-10-30)

• Primary citation: Wang, S.F.,Jin, J.-Y.,Zeng, Z.H.,Tian, G.R.; Optical 2-benzyl-5-hydroxy4oxopentanoic acids against carboxypeptidase A: Synthesis, kinetic evaluation and X-ray crystallographic study; CHIN.CHEM.LETT., 21:159-162, 2010; DOI: 10.1016/j.cclet.2009.09.005

Experimental method

X-RAY DIFFRACTION (1.85 Å)