3FUP
Crystal structures of JAK1 and JAK2 inhibitor complexes
Summary for 3FUP
Entry DOI | 10.2210/pdb3fup/pdb |
Related | 2B7A 3EYG 3EYH |
Descriptor | Tyrosine-protein kinase JAK2, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile (3 entities in total) |
Functional Keywords | kinase, ptk domain, protein-inhibitor complex, atp-binding, chromosomal rearrangement, disease mutation, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69809.51 |
Authors | Williams, N.K.,Bamert, R.S.,Patel, O.,Fantino, E.,Rossjohn, J.,Lucet, I.S. (deposition date: 2009-01-14, release date: 2009-02-10, Last modification date: 2023-11-22) |
Primary citation | Williams, N.K.,Bamert, R.S.,Patel, O.,Wang, C.,Walden, P.M.,Wilks, A.F.,Fantino, E.,Rossjohn, J.,Lucet, I.S. Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J.Mol.Biol., 387:219-232, 2009 Cited by PubMed: 19361440DOI: 10.1016/j.jmb.2009.01.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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