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3FUC

Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit

Summary for 3FUC
Entry DOI10.2210/pdb3fuc/pdb
Related1lv8 1lvu 1v48
DescriptorPurine nucleoside phosphorylase, [5-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-1,1-difluoropentyl]phosphonic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordspurine nucleoside phosphorylase, recombinant, glycosyltransferase, transferase, 9-deazaguanine, multisubstrate analogue inhibitors, nucleoside-binding, phosphate-binding, binding site, trimer
Biological sourceBos taurus (Bovine)
Cellular locationCytoplasm, cytoskeleton : P55859
Total number of polymer chains3
Total formula weight96184.97
Authors
Bochtler, M.,Breer, K.,Bzowska, A.,Chojnowski, G.,Hashimoto, M.,Hikishima, S.,Narczyk, M.,Wielgus-Kutrowska, B.,Yokomatsu, T. (deposition date: 2009-01-14, release date: 2009-12-08, Last modification date: 2023-11-01)
Primary citationChojnowski, G.,Breer, K.,Narczyk, M.,Wielgus-Kutrowska, B.,Czapinska, H.,Hashimoto, M.,Hikishima, S.,Yokomatsu, T.,Bochtler, M.,Girstun, A.,Staron, K.,Bzowska, A.
1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.
Biochem.Biophys.Res.Commun., 391:703-708, 2010
Cited by
PubMed: 19944078
DOI: 10.1016/j.bbrc.2009.11.124
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation

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数据于2024-03-27公开中

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