3FUC
Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit
Summary for 3FUC
Entry DOI | 10.2210/pdb3fuc/pdb |
Related | 1lv8 1lvu 1v48 |
Descriptor | Purine nucleoside phosphorylase, [5-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-1,1-difluoropentyl]phosphonic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | purine nucleoside phosphorylase, recombinant, glycosyltransferase, transferase, 9-deazaguanine, multisubstrate analogue inhibitors, nucleoside-binding, phosphate-binding, binding site, trimer |
Biological source | Bos taurus (Bovine) |
Cellular location | Cytoplasm, cytoskeleton : P55859 |
Total number of polymer chains | 3 |
Total formula weight | 96184.97 |
Authors | Bochtler, M.,Breer, K.,Bzowska, A.,Chojnowski, G.,Hashimoto, M.,Hikishima, S.,Narczyk, M.,Wielgus-Kutrowska, B.,Yokomatsu, T. (deposition date: 2009-01-14, release date: 2009-12-08, Last modification date: 2023-11-01) |
Primary citation | Chojnowski, G.,Breer, K.,Narczyk, M.,Wielgus-Kutrowska, B.,Czapinska, H.,Hashimoto, M.,Hikishima, S.,Yokomatsu, T.,Bochtler, M.,Girstun, A.,Staron, K.,Bzowska, A. 1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state. Biochem.Biophys.Res.Commun., 391:703-708, 2010 Cited by PubMed: 19944078DOI: 10.1016/j.bbrc.2009.11.124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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