3FUC

Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit

3FUC の概要

• エントリーDOI: 10.2210/pdb3fuc/pdb
• 関連するPDBエントリー: 1lv8 1lvu 1v48
• 分子名称: Purine nucleoside phosphorylase, [5-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-1,1-difluoropentyl]phosphonic acid, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: purine nucleoside phosphorylase, recombinant, glycosyltransferase, transferase, 9-deazaguanine, multisubstrate analogue inhibitors, nucleoside-binding, phosphate-binding, binding site, trimer
• 由来する生物種: Bos taurus (Bovine)
• 細胞内の位置: Cytoplasm, cytoskeleton : P55859
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 96184.97

構造登録者

Bochtler, M.,Breer, K.,Bzowska, A.,Chojnowski, G.,Hashimoto, M.,Hikishima, S.,Narczyk, M.,Wielgus-Kutrowska, B.,Yokomatsu, T. (登録日: 2009-01-14, 公開日: 2009-12-08, 最終更新日: 2023-11-01)

• 主引用文献: Chojnowski, G.,Breer, K.,Narczyk, M.,Wielgus-Kutrowska, B.,Czapinska, H.,Hashimoto, M.,Hikishima, S.,Yokomatsu, T.,Bochtler, M.,Girstun, A.,Staron, K.,Bzowska, A.; 1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.; Biochem.Biophys.Res.Commun., 391:703-708, 2010; PubMed: 19944078; DOI: 10.1016/j.bbrc.2009.11.124

実験手法

X-RAY DIFFRACTION (1.45 Å)