3FT8
Structure of HSP90 bound with a noval fragment.
Summary for 3FT8
Entry DOI | 10.2210/pdb3ft8/pdb |
Related | 3FT5 |
Descriptor | Heat shock protein HSP 90-alpha, (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime (3 entities in total) |
Functional Keywords | hsp90 n-terminal nucleotide binding domain, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 28322.72 |
Authors | Barker, J.B.,Cheng, R.K.Y.,Palan, S.,Felicetti, B. (deposition date: 2009-01-12, release date: 2009-06-30, Last modification date: 2024-02-21) |
Primary citation | Barker, J.J.,Barker, O.,Boggio, R.,Chauhan, V.,Cheng, R.K.,Corden, V.,Courtney, S.M.,Edwards, N.,Falque, V.M.,Fusar, F.,Gardiner, M.,Hamelin, E.M.,Hesterkamp, T.,Ichihara, O.,Jones, R.S.,Mather, O.,Mercurio, C.,Minucci, S.,Montalbetti, C.A.,Muller, A.,Patel, D.,Phillips, B.G.,Varasi, M.,Whittaker, M.,Winkler, D.,Yarnold, C.J. Fragment-based identification of Hsp90 inhibitors. Chemmedchem, 4:963-966, 2009 Cited by PubMed: 19301319DOI: 10.1002/cmdc.200900011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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