3FT8

Structure of HSP90 bound with a noval fragment.

Summary for 3FT8

Entry DOI	10.2210/pdb3ft8/pdb
Related	3FT5
Descriptor	Heat shock protein HSP 90-alpha, (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime (3 entities in total)
Functional Keywords	hsp90 n-terminal nucleotide binding domain, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	28322.72
Authors	Barker, J.B.,Cheng, R.K.Y.,Palan, S.,Felicetti, B. (deposition date: 2009-01-12, release date: 2009-06-30, Last modification date: 2024-02-21)
Primary citation	Barker, J.J.,Barker, O.,Boggio, R.,Chauhan, V.,Cheng, R.K.,Corden, V.,Courtney, S.M.,Edwards, N.,Falque, V.M.,Fusar, F.,Gardiner, M.,Hamelin, E.M.,Hesterkamp, T.,Ichihara, O.,Jones, R.S.,Mather, O.,Mercurio, C.,Minucci, S.,Montalbetti, C.A.,Muller, A.,Patel, D.,Phillips, B.G.,Varasi, M.,Whittaker, M.,Winkler, D.,Yarnold, C.J. Fragment-based identification of Hsp90 inhibitors. Chemmedchem, 4:963-966, 2009 Cited by PubMed: 19301319 DOI: 10.1002/cmdc.200900011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation