3FS1
Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment
Summary for 3FS1
Entry DOI | 10.2210/pdb3fs1/pdb |
Related | 1PZL |
Descriptor | Hepatocyte nuclear factor 4-alpha, PPARgamma Coactivator-1a (PGC-1a), MYRISTIC ACID, ... (4 entities in total) |
Functional Keywords | nuclear receptor, coactivator, lxxll motif, mody, diabetes, alternative promoter usage, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P41235 |
Total number of polymer chains | 2 |
Total formula weight | 27005.58 |
Authors | |
Primary citation | Rha, G.B.,Wu, G.,Shoelson, S.E.,Chi, Y.I. Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation J.Biol.Chem., 284:35165-35176, 2009 Cited by PubMed: 19846556DOI: 10.1074/jbc.M109.052506 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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