3FS1

Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment

3FS1 の概要

• エントリーDOI: 10.2210/pdb3fs1/pdb
• 関連するPDBエントリー: 1PZL
• 分子名称: Hepatocyte nuclear factor 4-alpha, PPARgamma Coactivator-1a (PGC-1a), MYRISTIC ACID, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, coactivator, lxxll motif, mody, diabetes, alternative promoter usage, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P41235
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27005.58

構造登録者

Rha, G.,Wu, G.,Chi, Y. (登録日: 2009-01-08, 公開日: 2009-10-27, 最終更新日: 2023-09-06)

• 主引用文献: Rha, G.B.,Wu, G.,Shoelson, S.E.,Chi, Y.I.; Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation; J.Biol.Chem., 284:35165-35176, 2009; PubMed: 19846556; DOI: 10.1074/jbc.M109.052506

実験手法

X-RAY DIFFRACTION (2.2 Å)