3FRU

NEONATAL FC RECEPTOR, PH 6.5

「1FRU」から置き換えられました

3FRU の概要

• エントリーDOI: 10.2210/pdb3fru/pdb
• 分子名称: NEONATAL FC RECEPTOR, BETA-2-MICROGLOBULIN, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: complex (immunoglobulin-binding protein), complex (immunoglobulin-binding protein) complex, complex (immunoglobulin/binding protein)
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 129314.76

構造登録者

Vaughn, D.E.,Burmeister, W.P.,Bjorkman, P.J. (登録日: 1997-12-22, 公開日: 1998-06-10, 最終更新日: 2025-03-26)

主引用文献

Vaughn, D.E.,Bjorkman, P.J.
Structural basis of pH-dependent antibody binding by the neonatal Fc receptor.
Structure, 6:63-73, 1998

PubMed Abstract: The neonatal Fc receptor (FcRn) mediates the transcytosis of maternal immunoglobulin G (IgG) across fetal and/or neonatal tissues for the acquisition of passive immunity. In adults, FcRn is involved in the maintenance of high serum IgG levels. Both processes are mediated by pH-dependent IgG binding to FcRn-FcRn binds to IgG with nanomolar affinity at pH 6, but shows no detectable binding at pH 7.5. At pH 6, FcRn is more thermally stable and the dissociation rate of its light chain is an order of magnitude slower than at pH 8.0. Comparison of the structures of FcRn at pH 6.5 and pH 8 allows an analysis of the structural basis for the receptor's pH-dependent ligand binding and stability.

PubMed: 9493268
DOI: 10.1016/S0969-2126(98)00008-2

実験手法

X-RAY DIFFRACTION (2.2 Å)