3FR0

Human glucokinase in complex with 2-amino benzamide activator

Summary for 3FR0

Entry DOI	10.2210/pdb3fr0/pdb
Related	1V4S 1V4T 3F9M
Descriptor	Glucokinase, alpha-D-glucopyranose, 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, ... (5 entities in total)
Functional Keywords	hexokinase iv, allosteric enzyme, diabetes, alternative splicing, atp-binding, diabetes mellitus, disease mutation, glycolysis, kinase, nucleotide-binding, polymorphism, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	51528.48
Authors	Kamata, K. (deposition date: 2009-01-08, release date: 2009-02-17, Last modification date: 2023-11-01)
Primary citation	Nishimura, T.,Iino, T.,Mitsuya, M.,Bamba, M.,Watanabe, H.,Tsukahara, D.,Kamata, K.,Sasaki, K.,Ohyama, S.,Hosaka, H.,Futamura, M.,Nagata, Y.,Eiki, J. Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators Bioorg.Med.Chem.Lett., 19:1357-1360, 2009 Cited by PubMed Abstract: The identification and structure-activity-relationships (SARs) of novel 2-amino benzamide glucokinase activators are described. Compounds in this series were developed to be potent GK activators, and their binding mode to the GK protein was determined by crystal structure analysis. In vivo pharmacokinetic and acute in vivo efficacy studies of compound 18 are also described. PubMed: 19188063 DOI: 10.1016/j.bmcl.2009.01.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation