3FR0

Human glucokinase in complex with 2-amino benzamide activator

3FR0 の概要

• エントリーDOI: 10.2210/pdb3fr0/pdb
• 関連するPDBエントリー: 1V4S 1V4T 3F9M
• 分子名称: Glucokinase, alpha-D-glucopyranose, 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, ... (5 entities in total)
• 機能のキーワード: hexokinase iv, allosteric enzyme, diabetes, alternative splicing, atp-binding, diabetes mellitus, disease mutation, glycolysis, kinase, nucleotide-binding, polymorphism, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51528.48

構造登録者

Kamata, K. (登録日: 2009-01-08, 公開日: 2009-02-17, 最終更新日: 2023-11-01)

主引用文献

Nishimura, T.,Iino, T.,Mitsuya, M.,Bamba, M.,Watanabe, H.,Tsukahara, D.,Kamata, K.,Sasaki, K.,Ohyama, S.,Hosaka, H.,Futamura, M.,Nagata, Y.,Eiki, J.
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
Bioorg.Med.Chem.Lett., 19:1357-1360, 2009

PubMed Abstract: The identification and structure-activity-relationships (SARs) of novel 2-amino benzamide glucokinase activators are described. Compounds in this series were developed to be potent GK activators, and their binding mode to the GK protein was determined by crystal structure analysis. In vivo pharmacokinetic and acute in vivo efficacy studies of compound 18 are also described.

PubMed: 19188063
DOI: 10.1016/j.bmcl.2009.01.053

実験手法

X-RAY DIFFRACTION (2.7 Å)