3FQX

Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes

3FQX の概要

• エントリーDOI: 10.2210/pdb3fqx/pdb
• 関連するPDBエントリー: 3FQN 3FQR 3FQT 3FQU 3FQW
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, phospho-peptide 1097-1105 from insulin receptor substrate 2 (IRS2): RVA(Sep)PTSGV, ... (7 entities in total)
• 機能のキーワード: immune system, phosphorylation, glycoprotein, immune response, membrane, mhc i, phosphoprotein, transmembrane, disease mutation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, cancer, tcr, self-epitope
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45238.01

構造登録者

Petersen, J.,Rossjohn, J. (登録日: 2009-01-07, 公開日: 2009-03-03, 最終更新日: 2023-11-01)

• 主引用文献: Petersen, J.,Wurzbacher, S.J.,Williamson, N.A.,Ramarathinam, S.H.,Reid, H.H.,Nair, A.K.,Zhao, A.Y.,Nastovska, R.,Rudge, G.,Rossjohn, J.,Purcell, A.W.; Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes; Proc.Natl.Acad.Sci.Usa, 106:2776-2781, 2009; PubMed: 19196958; DOI: 10.1073/pnas.0812901106

実験手法

X-RAY DIFFRACTION (1.7 Å)