3FQH

Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole

Summary for 3FQH

Entry DOI	10.2210/pdb3fqh/pdb
Related	3FQE 3FQS
Descriptor	Tyrosine-protein kinase SYK, N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide (3 entities in total)
Functional Keywords	syk, spleen typrosine kinase, kinase inhibitor, 7-azaindole, alternative splicing, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	68492.86
Authors	Kuglstatter, A.,Villasenor, A.G. (deposition date: 2009-01-07, release date: 2009-03-10, Last modification date: 2023-09-06)
Primary citation	Villasenor, A.G.,Kondru, R.,Ho, H.,Wang, S.,Papp, E.,Shaw, D.,Barnett, J.W.,Browner, M.F.,Kuglstatter, A. Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chem.Biol.Drug Des., 73:466-470, 2009 Cited by PubMed: 19220318 DOI: 10.1111/j.1747-0285.2009.00785.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation