3FQH

Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase SYK	polymer	291	33884.0	2	UniProt (P43405) Pfam (PF07714)	Homo sapiens (Human)	Spleen tyrosine kinase
2	C, D (A, B)	N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide	non-polymer		362.4	2	Chemie (057)
3	E, F (A, B)	water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	expression tag
Ala 354	-	expression tag
Leu 355	-	expression tag
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67768.0
Non-Polymers*	Number of molecules	2
	Total formula weight	724.9
All*	Total formula weight	68492.9

*Water molecules are not included.