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3FQH

Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Tyrosine-protein kinase SYKpolymer29133884.02UniProt (P43405)
Pfam (PF07714)
Homo sapiens (Human)Spleen tyrosine kinase
2C, D
(A, B)
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamidenon-polymer362.42Chemie (057)
3E, F
(A, B)
waterwater18.0108Chemie (HOH)
Sequence modifications
A, B: 356 - 635 (UniProt: P43405)
PDBExternal DatabaseDetails
Met 353-expression tag
Ala 354-expression tag
Leu 355-expression tag
Glu 636-expression tag
Gly 637-expression tag
His 638-expression tag
His 639-expression tag
His 640-expression tag
His 641-expression tag
His 642-expression tag
His 643-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight67768.0
Non-Polymers*Number of molecules2
Total formula weight724.9
All*Total formula weight68492.9
*Water molecules are not included.

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PDB entries from 2025-07-23

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