3FQH
Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase SYK | polymer | 291 | 33884.0 | 2 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (Human) | Spleen tyrosine kinase |
2 | A, B | N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide | non-polymer | 362.4 | 2 | Chemie (057) | |||
3 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A, B: 356 - 635 (UniProt: P43405)
PDB | External Database | Details |
---|---|---|
Met 353 | - | expression tag |
Ala 354 | - | expression tag |
Leu 355 | - | expression tag |
Glu 636 | - | expression tag |
Gly 637 | - | expression tag |
His 638 | - | expression tag |
His 639 | - | expression tag |
His 640 | - | expression tag |
His 641 | - | expression tag |
His 642 | - | expression tag |
His 643 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 67768.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 724.9 | |
All* | Total formula weight | 68492.9 |