3FQH

Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole

3FQH の概要

• エントリーDOI: 10.2210/pdb3fqh/pdb
• 関連するPDBエントリー: 3FQE 3FQS
• 分子名称: Tyrosine-protein kinase SYK, N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide (3 entities in total)
• 機能のキーワード: syk, spleen typrosine kinase, kinase inhibitor, 7-azaindole, alternative splicing, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68492.86

構造登録者

Kuglstatter, A.,Villasenor, A.G. (登録日: 2009-01-07, 公開日: 2009-03-10, 最終更新日: 2023-09-06)

• 主引用文献: Villasenor, A.G.,Kondru, R.,Ho, H.,Wang, S.,Papp, E.,Shaw, D.,Barnett, J.W.,Browner, M.F.,Kuglstatter, A.; Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes.; Chem.Biol.Drug Des., 73:466-470, 2009; PubMed: 19220318; DOI: 10.1111/j.1747-0285.2009.00785.x

実験手法

X-RAY DIFFRACTION (2.26 Å)