Saccharomyces cerevisiae THI4p is a suicide thiamin thiazole synthase

Replaces:  2GJC

Summary for 3FPZ

Related1RP0 2GJC
DescriptorThiazole biosynthetic enzyme, ADENOSINE DIPHOSPHATE 5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywordsthiazole biosynthetic enzyme in yeast, fad, mitochondrion, nad, thiamine biosynthesis, transit peptide, biosynthetic protein
Biological sourceSaccharomyces cerevisiae (yeast)
Cellular locationCytoplasm P32318
Total number of polymer chains2
Total molecular weight71466.55
Bale, S.,Chatterjee, A.,Dorrestein, P.C.,Begley, T.P.,Ealick, S.E. (deposition date: 2009-01-06, release date: 2010-01-19, Last modification date: 2017-11-01)
Primary citation
Chatterjee, A.,Abeydeera, N.D.,Bale, S.,Pai, P.J.,Dorrestein, P.C.,Russell, D.H.,Ealick, S.E.,Begley, T.P.
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
Nature, 478:542-546, 2011
PubMed: 22031445 (PDB entries with the same primary citation)
DOI: 10.1038/nature10503
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2322 0.5% 1.4% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21