Crystal structure of E.coli MacA

Summary for 3FPP

DescriptorMacrolide-specific efflux protein macA (1 entity in total)
Functional Keywordshexameric assembly, membrane fusion protein, drug efflux pump, periplasmic protein, antibiotic resistance, cell inner membrane, cell membrane, membrane, transport, membrane protein
Biological sourceEscherichia coli
Cellular locationCell inner membrane; Peripheral membrane protein P75830
Total number of polymer chains2
Total molecular weight74374.48
Yum, S.,Xu, Y.,Piao, S.,Ha, N.-C. (deposition date: 2009-01-06, release date: 2009-04-28, Last modification date: 2011-07-13)
Primary citation
Yum, S.,Xu, Y.,Piao, S.,Sim, S.-H.,Kim, H.-M.,Jo, W.-S.,Kim, K.-J.,Kweon, H.-S.,Jeong, M.-H.,Jeon, H.,Lee, K.,Ha, N.-C.
Crystal structure of the periplasmic component of a tripartite macrolide-specific efflux pump
J.Mol.Biol., 387:1286-1297, 2009
PubMed: 19254725 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2009.02.048
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.351467.8%13.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report