3FOL

Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide VNDIFERI

3FOL の概要

• エントリーDOI: 10.2210/pdb3fol/pdb
• 関連するPDBエントリー: 3FOM 3FON
• 分子名称: MHC, Beta-2-microglobulin, 8 residue synthetic peptide, ... (4 entities in total)
• 機能のキーワード: class i mhc, peptide complex, diabetes-protective effect, immune response, immunoglobulin domain, mhc i, secreted, chromosomal protein, dna-binding, methylation, nucleosome core, nucleus, phosphoprotein, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Secreted: P01887
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44328.78

構造登録者

Brims, D.R.,Qian, J.,Jarchum, I.,Yamada, T.,Mikesh, L.,Palmieri, E.,Lund, T.,Hattori, M.,Shabanowitz, J.,Hunt, D.F.,Ramagopal, U.A.,Malashkevich, V.N.,Almo, S.C.,Nathenson, S.G.,DiLorenzo, T.P. (登録日: 2008-12-30, 公開日: 2010-01-12, 最終更新日: 2017-11-01)

• 主引用文献: Brims, D.R.,Qian, J.,Jarchum, I.,Mikesh, L.,Palmieri, E.,Ramagopal, U.A.,Malashkevich, V.N.,Chaparro, R.J.,Lund, T.,Hattori, M.,Shabanowitz, J.,Hunt, D.F.,Nathenson, S.G.,Almo, S.C.,Dilorenzo, T.P.; Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect; Int.Immunol., 22:191-203, 2010; PubMed: 20093428; DOI: 10.1093/intimm/dxp127

実験手法

X-RAY DIFFRACTION (2.5 Å)