3FO1

Crystal structure of hapten complex of catalytic elimination antibody 13G5 (Glu(L39)Ala mutant)

Summary for 3FO1

Entry DOI	10.2210/pdb3fo1/pdb
Related	2GJZ 2GK0 3FO0 3FO2
Descriptor	Catalytic antibody Fab 13G5 kappa light chain chimera, Catalytic antibody Fab 13G5 IgG2b heavy chain chimera, 5-[(2-AMINO-1H-BENZIMIDAZOL-6-YL)AMINO]-5-OXOPENTANOIC ACID, ... (4 entities in total)
Functional Keywords	immunoglobulin, catalytic antibody, chimeric fab, hapten complex, acid base catalysis, proton transfer, immunoglobulin domain, immune system
Biological source	Mus musculus, Homo sapiens (Mouse, Human) More
Total number of polymer chains	4
Total formula weight	97006.46
Authors	Debler, E.W.,Wilson, I.A. (deposition date: 2008-12-27, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	Debler, E.W.,Muller, R.,Hilvert, D.,Wilson, I.A. An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket. Proc.Natl.Acad.Sci.USA, 106:18539-18544, 2009 Cited by PubMed: 19846764 DOI: 10.1073/pnas.0902700106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation