3FNG

Crystal structure of InhA bound to triclosan derivative

3FNG の概要

• エントリーDOI: 10.2210/pdb3fng/pdb
• 関連するPDBエントリー: 3FNE 3FNF 3FNH
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol, ... (4 entities in total)
• 機能のキーワード: inha, triclosan, tuberculosis, antibiotic resistance, fatty acid biosynthesis, lipid synthesis, nad, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29569.47

構造登録者

Wang, F. (登録日: 2008-12-24, 公開日: 2009-01-20, 最終更新日: 2023-09-06)

• 主引用文献: Freundlich, J.S.,Wang, F.,Vilcheze, C.,Gulten, G.,Langley, R.,Schiehser, G.A.,Jacobus, D.P.,Jacobs, W.R.,Sacchettini, J.C.; Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.; Chemmedchem, 4:241-248, 2009; PubMed: 19130456; DOI: 10.1002/cmdc.200800261

実験手法

X-RAY DIFFRACTION (1.97 Å)