3FNF

Crystal structure of InhA bound to triclosan derivative

Summary for 3FNF

• Entry DOI: 10.2210/pdb3fnf/pdb
• Related: 3FNE 3FNG 3FNH
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-benzyl-2-(2,4-dichlorophenoxy)phenol, ... (4 entities in total)
• Functional Keywords: inha, triclosan, tuberculosis, antibiotic resistance, fatty acid biosynthesis, lipid synthesis, nad, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 118253.70

Authors

Wang, F. (deposition date: 2008-12-24, release date: 2009-01-20, Last modification date: 2023-09-06)

• Primary citation: Freundlich, J.S.,Wang, F.,Vilcheze, C.,Gulten, G.,Langley, R.,Schiehser, G.A.,Jacobus, D.P.,Jacobs, W.R.,Sacchettini, J.C.; Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.; Chemmedchem, 4:241-248, 2009; PubMed: 19130456; DOI: 10.1002/cmdc.200800261

Experimental method

X-RAY DIFFRACTION (2.3 Å)