3FMD

Crystal Structure of Human Haspin with an Isoquinoline ligand

Summary for 3FMD

• Entry DOI: 10.2210/pdb3fmd/pdb
• Descriptor: Serine/threonine-protein kinase haspin, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, NICKEL (II) ION, ... (5 entities in total)
• Functional Keywords: haspin, germ cell associated 2, haploid germ cell specific nuclear protein kinase, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q8TF76
• Total number of polymer chains: 1
• Total formula weight: 41278.61

Authors

Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-12-21, release date: 2008-12-30, Last modification date: 2023-09-06)

• Primary citation: Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.; Crystal Structure of Human Haspin with an Isoquinoline ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)