3FLF
Thermolysin inhibition
Summary for 3FLF
Entry DOI | 10.2210/pdb3flf/pdb |
Related | 4TMN 5TMN 6TMN |
Related PRD ID | PRD_000652 |
Descriptor | Thermolysin, CALCIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | protease phosphonamidate inhibitor, hydrolase, metal-binding, metalloprotease, protease, secreted, zymogen |
Biological source | Bacillus thermoproteolyticus |
Total number of polymer chains | 1 |
Total formula weight | 35227.70 |
Authors | Englert, L.,Biela, A.,Heine, A.,Klebe, G. (deposition date: 2008-12-18, release date: 2010-01-12, Last modification date: 2023-09-06) |
Primary citation | Englert, L.,Biela, A.,Zayed, M.,Heine, A.,Hangauer, D.,Klebe, G. Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: binding of phosphonamidate to the S1'-pocket of thermolysin. Biochim.Biophys.Acta, 1800:1192-1202, 2010 Cited by PubMed: 20600625DOI: 10.1016/j.bbagen.2010.06.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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