3FKB

Structure of NDPK H122G and tenofovir-diphosphate

3FKB の概要

• エントリーDOI: 10.2210/pdb3fkb/pdb
• 関連するPDBエントリー: 1b4s 1f3f 2bef
• 分子名称: Nucleoside diphosphate kinase, cytosolic, [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phosphonooxy-phosphinic acid, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: an hexamer structure, atp-binding, kinase, magnesium, metal-binding, nucleotide metabolism, nucleotide-binding, phosphoprotein, transferase
• 由来する生物種: Dictyostelium discoideum (Slime mold)
• 細胞内の位置: Cytoplasm: P22887
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 103334.94

構造登録者

Morera, S.,Chen, Y.X. (登録日: 2008-12-16, 公開日: 2009-09-29, 最終更新日: 2023-11-01)

• 主引用文献: Koch, K.,Chen, Y.X.,Feng, J.Y.,Borroto-Esoda, K.,Deville-Bonne, D.,Gallois-Montbrun, S.,Janin, J.,Morera, S.; Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivatives; Nucleosides Nucleotides Nucleic Acids, 28:776-792, 2009; PubMed: 20183617; DOI: 10.1080/15257770903155899

実験手法

X-RAY DIFFRACTION (1.65 Å)