3FJT

Crystal structure of a human Fc fragment engineered for extended serum half-life

3FJT の概要

• エントリーDOI: 10.2210/pdb3fjt/pdb
• 分子名称: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: fc, igg1, fcrn binding, ch3-ch3 association, glycoprotein, immunoglobulin c region, immunoglobulin domain, secreted, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted : P01857
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50458.17

構造登録者

Oganesyan, V.,Wu, H.,Dall'Acqua, W.F. (登録日: 2008-12-15, 公開日: 2009-03-24, 最終更新日: 2021-10-20)

• 主引用文献: Oganesyan, V.,Damschroder, M.M.,Woods, R.M.,Cook, K.E.,Wu, H.,Dall'acqua, W.F.; Structural characterization of a human Fc fragment engineered for extended serum half-life.; Mol.Immunol., 46:1750-1755, 2009; PubMed: 19250681; DOI: 10.1016/j.molimm.2009.01.026

実験手法

X-RAY DIFFRACTION (2.5 Å)