3FJN
The crystal structure of 17-alpha hydroxysteroid dehydrogenase Y224D mutant.
Summary for 3FJN
Entry DOI | 10.2210/pdb3fjn/pdb |
Descriptor | Aldo-keto reductase family 1 member C21, ACETATE ION (3 entities in total) |
Functional Keywords | aldo-keto reductase, 17-alpha-hydroxysteroid dehydrogenase, cytoplasm, lipid metabolism, nadp, oxidoreductase, phosphoprotein, steroid metabolism |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm (By similarity): Q91WR5 |
Total number of polymer chains | 2 |
Total formula weight | 73989.16 |
Authors | Dhagat, U.,El-Kabbani, O. (deposition date: 2008-12-14, release date: 2009-11-24, Last modification date: 2023-11-01) |
Primary citation | Dhagat, U.,Endo, S.,Mamiya, H.,Hara, A.,El-Kabbani, O. Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme Acta Crystallogr.,Sect.D, 66:198-204, 2010 Cited by PubMed: 20124700DOI: 10.1107/S0907444909051464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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